Apolipoprotein E (ApoE) is a 34 kDa protein involves in fats metabolism. It is located at human chromosome 19 and associated with Alzheimer's disease and cardiovascular disease. ApoE gene has three polymorphic alleles (ε2, ε3, and ε4) that encode three protein isoforms—E2 (Cys112/Cys158), E3 (Cys112/Arg158) and E4 (Arg112/Arg158), everyone inherits one of three alleles from each parent and resulting in six possible genotypes—ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε3, ε3/ε4, ε4/ε4. 
According to previous studies, if there is an ε4 in ApoE may cause high risk of late onset Alzheimer’s disease. Furthermore, Familial type III hyperlipoproteinemia is frequently mentioned associated with the ApoE ε2/ε2.

Qexp-MDx ApoE Genotyping kit provides a fast and simple method of direct Multiplex PCR without DNA extraction in whole blood.